MSU study finds shampoo-like gel may help prevent chemo-related hair loss
Researchers at Michigan State University developed a shampoo-like hydrogel meant to be applied to the scalp shortly before chemotherapy. The idea is simple: temporarily reduce blood flow around hair follicles so fewer chemo drugs reach them. In preclinical (animal) studies, this approach narrowed small blood vessels in the skin and helped preserve hair follicles after chemotherapy. The concept is promising, but it’s not yet tested in people and not available for clinical use.
How the gel works
The gel carries vasoconstricting medicines—including a familiar topical anesthetic—that briefly tighten tiny blood vessels in the scalp.
It is temperature-responsive: thicker at body temperature so it stays put during the infusion, then thinner when cooled so it rinses off easily.
Because the medicines act locally, the goal is to limit chemo exposure only in the scalp without affecting treatment elsewhere in the body. That still needs confirmation in human studies.
What the study showed
In lab and animal tests, the hydrogel adhered well, released its medicines in a controlled way, and reduced micro-vessel diameter near hair follicles.
Only minimal amounts of the medicines were detected away from the application site in these early models.
The study provides proof-of-mechanism—that controlling scalp blood flow could shield follicles—setting the stage for human trials.
How this compares to scalp cooling (cold caps)
Cold caps are the current, widely available method to reduce chemo-related hair loss. They work by cooling the scalp, which also constricts blood vessels. Many patients benefit, but cold caps can be time-intensive, uncomfortable for some, and not appropriate for every cancer type or regimen.
The MSU gel aims to deliver similar physiology without freezing, potentially simplifying hair preservation—if future clinical trials show it’s safe and effective.
What this means for patients and caregivers right now
The hydrogel is experimental and not available outside research.
If hair preservation is a priority, ask your oncology team about scalp cooling at your infusion center and whether it fits your specific chemotherapy plan.
Discuss hair-care strategies to make shedding less stressful, whether or not you use cold caps.
Gentle hair-care tips during chemotherapy
Wash less often with mild shampoo; avoid very hot water.
Skip heat styling (blow-dryers, curling/flat irons) and chemical treatments.
Use a wide-tooth comb and avoid tight styles that tug on hair.
Consider a shorter cut before treatment to make shedding more manageable.
After treatment, expect early “peach fuzz” followed by gradual regrowth; temporary texture or color changes are common.
Questions to ask your care team
Am I a candidate for scalp cooling given my chemo regimen and cancer type?
What results have you seen with cold caps at this center?
Are there upcoming clinical trials here or nearby testing topical hydrogels for hair preservation?
What support services are available if I lose my hair (wigs, head coverings, counseling)?
Bottom line
The MSU study introduces a thoughtful, patient-centered idea: a shampoo-like hydrogel that may protect hair during chemotherapy by temporarily tightening scalp blood vessels. Early animal data are encouraging, but human trials are the essential next step. For now, talk with your oncology team about scalp cooling and supportive hair-care options while we watch for clinical studies of this gel.
Reference
Hydrogel-based drug delivery system designed for chemotherapy-induced alopecia
For more information on how HuMOLYTE can support your gut health during chemotherapy, visit our product page or consult your health care provider.
This blog was reviewed by Dr. Sourabh Kharait.
This blog is for educational purposes only and is not intended as medical advice. Always consult with your healthcare provider before making any changes to your treatment plan, hydration strategies, or diet. The information provided here is based on general insights and may not apply to individual circumstances.
