UCSF Study: Gut Bacteria Can Help Reduce Chemo Side Effects
For people undergoing chemotherapy—especially those with colorectal cancer—side effects like gut pain, diarrhea, and fatigue can feel overwhelming. One common chemotherapy drug, capecitabine (CAP), is effective at fighting cancer, but it can also disrupt the balance of bacteria in the gut.
Gut Bacteria: Your Hidden Ally
A new study from UCSF followed cancer patients taking capecitabine. Researchers found that the drug didn’t just affect cancer cells—it also changed the gut microbiome, the collection of trillions of bacteria living in your digestive system.
One group of gut bacteria stood out. These microbes carried a special gene called preTA, which helps break down the harsh chemicals from chemo into gentler forms. Mice given these helpful bacteria during treatment experienced fewer side effects and stayed healthier.
The takeaway? A strong, healthy microbiome may protect your body during chemotherapy.
How HuMOLYTE Can Help*
Chemotherapy, infections, alcohol, and even stress can damage the gut microbiome, sometimes for weeks or months. That’s why HuMOLYTE focuses on restoring microbial balance—especially when your gut needs it most.
Our solution? 2’-FL (2’-fucosyllactose)—a natural prebiotic that feeds the “good bugs” in your gut, especially Bifidobacteria. These bacteria are essential for a healthy microbiome and may help your body recover faster after chemo.
By promoting the growth of these beneficial microbes, HuMOLYTE helps:
Rebuild your gut barrier
Support immune function
Reduce inflammation
Maintain microbial balance during and after treatment
In short, we help your gut bounce back—so your body can keep fighting cancer with fewer setbacks.
What You Can Do Today
Even if you’re still in treatment, there are steps you can take now to support your gut:
✅ Eat a variety of fiber-rich foods like fruits, vegetables, and whole grains
✅ Avoid unnecessary antibiotics unless prescribed
✅ Support your microbiome with targeted prebiotics like HuMOLYTE’s 2’-FL
And always talk to your care team before starting new supplements.
The Bottom Line
Your gut microbiome isn’t just along for the ride—it’s a powerful part of your overall health, especially during cancer treatment. Thanks to new science, we now know it can help reduce chemo side effects.
With HuMOLYTE’s targeted support, you can nourish your gut microbiome and take one more step toward a smoother recovery.
Reference
Expansion of a bacterial operon during cancer treatment ameliorates fluoropyrimidine toxicity
For more information on how HuMOLYTE can support your gut health during chemotherapy, visit our product page or consult your health care provider.
This blog was reviewed by Dr. Sourabh Kharait.
This blog is for educational purposes only and is not intended as medical advice. Always consult with your healthcare provider before making any changes to your treatment plan, hydration strategies, or diet. The information provided here is based on general insights and may not apply to individual circumstances.
