Study Shows Chemo Mouthpiece® Reduces Oral Pain and Opioid Use During Chemotherapy
Introduction
Oral mucositis is a common side effect of chemotherapy, affecting a large number of patients. It causes painful sores in the mouth and throat, making it difficult to eat, drink, or speak. In severe cases, it can lead to treatment delays, nutritional challenges, and increased dependence on opioid pain medications.
A new medical device, the Chemo Mouthpiece®, has been studied as a way to reduce this complication. Recent trial results provide encouraging evidence that the device can lower both oral pain and the need for opioid or other pain-relieving medications.
What Is the Chemo Mouthpiece®?
The Chemo Mouthpiece® is a reusable cryotherapy device. Cryotherapy, or cooling therapy, is already used in oncology to reduce oral mucositis, most commonly through ice chips. However, many patients find ice difficult to tolerate, and it does not cool all areas of the mouth evenly.
The device works by cooling the entire oral cavity more consistently, and it is designed to be used during chemotherapy infusions and for a short period afterward.
Study Overview
A randomized, controlled clinical trial tested the Chemo Mouthpiece® in patients undergoing chemotherapy across multiple cancer types and treatment regimens. The study included use of the device during infusion as well as for several days at home. Patients tracked their symptoms and pain medication use over two chemotherapy cycles.
Key Findings
Results from the trial showed:
46% reduction in oral pain symptoms compared to patients receiving standard supportive care.
68% reduction in opioid or other analgesic use in patients who used the device.
A majority of patients reported the device was tolerable and that they would recommend it to others.
No safety concerns were identified during the study.
Why the Findings Matter
These results highlight a potential new option for managing oral mucositis. Reducing pain not only improves quality of life but may also help patients maintain adequate nutrition and continue treatment without interruption. Lower reliance on opioids is another important benefit, given the risks of side effects and dependence.
Access and Use
The Chemo Mouthpiece® is FDA-cleared for reducing the severity and incidence of chemotherapy-induced oral mucositis in adults. It is available by prescription and can be used both in a clinical setting and at home under guidance from a care team.
Conclusion
Oral mucositis remains a significant challenge for people receiving chemotherapy. The Chemo Mouthpiece® offers an evidence-based approach to reducing pain and minimizing the need for opioid medications. While additional research may continue to refine its use, this study suggests that cooling the mouth in a more consistent and patient-friendly way can provide meaningful relief during cancer treatment.
Reference
For more information on how HuMOLYTE can support your gut health during chemotherapy, visit our product page or consult your health care provider.
This blog was reviewed by Dr. Sourabh Kharait.
This blog is for educational purposes only and is not intended as medical advice. Always consult with your healthcare provider before making any changes to your treatment plan, hydration strategies, or diet. The information provided here is based on general insights and may not apply to individual circumstances.
